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. 2014 May;143(5):577–604. doi: 10.1085/jgp.201311123

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Figure 21. — Biphasic variation of beating rate as a function of RyR calcium sensitivity. Increasing RyR sensitivity increases rate up to a point, but higher sensitivity (lower IC50) produces a pathological premature diastolic calcium release, causing a kink in the phase-plane loop and paradoxical decrease in beating rate.