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. 2014 May;143(5):577–604. doi: 10.1085/jgp.201311123

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Figure 22. — Increasing SERCA pumping rate increases beating rate, as proposed in the coupled clocks theory. The largest effect is produced by increasing the V_max of the pump (represented by the model variable P_up), whereas increasing the pump affinity (red) makes a relatively modest contribution, possibly because of saturation of SERCA near the membrane.