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. 2014 May;143(5):577–604. doi: 10.1085/jgp.201311123

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Figure 23. — Effect of increasing SERCA pump rate (as would be produced by β-adrenergic stimulation) in a model cell with increased RyR sensitivity. This introduces a pathological regimen in which further stimulation causes paradoxical decrease of the beating rate as a result of desynchronization of calcium and membrane clocks, producing the characteristic kink in the NCX phase-plane loop caused by premature diastolic calcium release.