Skip to main content
. 2013 Mar 25;10(4):317–329. doi: 10.1038/cmi.2012.77

Figure 8.

Figure 8

Effect of NOD1 and NOD2 ligands on the production of IgE, CCL5 and IL-13 in allergic asthmatic mice. (a) Serum was collected from allergic asthmatic mice with different treatments (n=4) for the determination of the fold increase for the production of serum total IgE using ELISA comparing with control mice. (b, c) Concentrations of CCL5 and IL-13 in BALF from allergic asthmatic mice with different treatments (n=4) were determined using mouse cytokine Bio-Plex assay reagent (Bio-Rad Laboratories, Inc., Hercules, CA, USA). *P<0.05, ***P<0.001 when compared with medium control, #P<0.05 when compared with ovalbumin treatment only. Ctrl: PBS control; OVA: ovalbumin; NOD1: NOD1 ligand iE-DAP; NOD2: NOD2 ligand MDP. BALF, bronchoalveolar lavage fluid; iE-DAP, γ-D-glutamyl-meso-diaminopimelic acid; MDP, muramyl dipeptide; NOD, nucleotide-binding oligomerization domain.