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. 2010 Mar 22;7(4):306–315. doi: 10.1038/cmi.2010.11

Figure 6.

Figure 6

Curcumin normalizes intracellular TGF-β and IL-10 in CD4+CD25+ Treg cells. Histogram overlay represents the intracellular TGF-β (left panels) and IL-10 (middle panels) levels in CD4+CD25+FoxP3+ Treg cell populations from the (a) peripheral circulation, (b) lymph nodes and (c) tumor sites of untreated or curcumin-treated normal and tumor-bearing mice. Right panels of (a–c) represent IL-10 levels in CD4+CD25+FoxP3− Treg cell populations. Filled histograms indicate the isotype controls for intracellular cytokine staining. Values are representatives of three independent experiments. TGF, transforming growth factor.