Table 2. Summary of the autoantibodies detected in PBC sera using indirect immunofluorescence (IIF), immunoblotting (IB) or other serological methods.
| Molecular targets (pattern) | Detection systems | PBC-specific | Prevalence in PBC (%) | |
|---|---|---|---|---|
| ANA | Sp100, PML, SUMO (nuclear dots) | IIF | ++ | 30–50 |
| gp210, NUP62 (rim-like) | IIF | ++ | 30–50 | |
| Anticentromere | IIF | − | 20 | |
| AMA | E2 subunits of 2-oxoacid dehydrogenase complexes, mainly PDC-E2 | IIF | +++ | 85–95 |
| ELISA, IB |
AMA, antimitochondrial autoantibody; ANA, antinuclear antibody; ELISA, enzyme-linked immunosorbent assay; NUP62, nuclear pore glycoprotein p62; PBC, primary biliary cirrhosis; PDC-E2, pyruvate dehydrogenase complex E2; PML, promyelocytic leukemia proteins; SUMO, small ubiquitin-like modifiers.