Table 1.

Gray value of the sections by IHC on the 21st day after intravenous injection of H22

Groups	n	Gray value ( $\overline{x}$ ± SE)
		MMP-2	MMP-9
A	6	168.3±5.7##	167.8±5.3##
B1	6	174.0±5.0##	174.2±1.8##
B2	6	178.8±7.0##	178.5±3.2##
C1	6	183.0±2.9*,#	177.8±7.5#
C2	6	184.5±4.8*,#	189.0±7.2*
D1	6	187.0±5.0*	192.5±5.4**,▲
D2	6	199.5±3.6**	202.2±3.9**

Notes: For MMP-2 and MMP-9 respectively

^*P<0.05

^**P<0.01 versus the A group

^#P<0.05

^##P<0.01 versus the D2 group

^▲P<0.05 versus the B1 group. A, control group; B1, paclitaxel 15 mg/kg; B2, paclitaxel 30 mg/kg; C1, paclitaxel-containing mixed micelles at 15 mg/kg; C2, paclitaxel-containing mixed micelles at 30 mg/kg; D1, folic acid and paclitaxel-containing mixed micelles at 15 mg/kg; D2, folic acid and paclitaxel-containing mixed micelles at 30 mg/kg.

Abbreviations: IHC, immunohistochemistry; H22, hepatoma 22; n, number; SE, standard error; MMP, matrix metalloproteinase.