Figure 1.

Hhex expression in the adult mouse and human pancreas. (A) Immunofluorescent labeling of an adult mouse pancreas reveals robust Hhex expression in Sst-producing δ cells. Hhex immunoreactivity is also detected in pancreatic ducts (arrow) and, at lower levels, in some acinar cells. (B–D) Hhex immunofluorescence is undetectable in insulin (Ins)-expressing β cells, glucagon (Glu)-expressing α cells, or PP (pancreatic polypeptide) cells. (E–H) In the adult human pancreas, HHEX (red) is also expressed in Sst -positive (green) δ cells rather than other endocrine cell types. Borders of islets are outlined in white.