Table 1. Demographic data of subjects included in population analysis.

Characteristic	Single dose 12.5 mg	Single dose 25 mg	Single dose 37.5 mg	Single dose 50 mg	Multiple dose 25 mg	Multiple dose 50 mg
Gender (male/female)	4/4	4/4	4/4	4/4	10/0	9/0
Age (years)	30.13±3.76	32.13±3.48	31.38±2.45	30.75±2.76	24.50±4.06	24.89±3.55
Height (cm)	166.00±8.60	163.25±8.71	164.50±6.57	165.25±4.43	171.80±4.52	173.22±5.26
Weight (kg)	60.25±7.27	60.00±5.35	60.88±6.64	60.38±6.59	64.40±7.12	66.11±7.65
BUN (μmol/L)	4.43±0.90	5.28±1.86	4.52±1.01	4.40±1.10	4.62±1.15	5.21±1.29
Cr (μmol/L)	52.95±9.12	52.25±11.89	53.40±9.96	51.48±9.20	61.57±9.43	64.72±9.40
Aspartate transaminase (U/L)	11.56±3.59	13.64±5.06	18.19±6.24	24.36±15.57	17.71±9.78	20.02±15.78
Alanine transaminase (U/L)	18.46±2.32	16.09±1.97	16.25±2.30	22.54±7.51	19.17±4.04	18.16±4.80