Table 3. Parameter estimates of the final model.
| Parameter | Estimates of the model parameters (SE%) | Bootstrapped median (95% CI) |
|---|---|---|
| Pharmacokinetic parameter | ||
| CL/F, L/h | 0.168 (7.1) | 0.166 (0.053–0.194) |
| V/F, L | 15.5 (6.3) | 15.4 (5.25–17.5) |
| Ka, 1/h | 0.0605 (9.9) | 0.0601 (0.0477–0.0711) |
| Tlag, h | 1.03 (14.0) | 1.05 (0.71–1.31) |
| θM for F | 0.674 (6.8) | 0.673 (0.57–0.75) |
| θGender for CL/F | 0.655 (6.8) | 0.666 (0.57–0.84) |
| Interindividual variability | ||
| CL/F, % | 33.3 (23.5) | 32.9 (25.1–62.8) |
| V/F, % | 42.7 (27.3) | 41.8 (30.0–63.0) |
| Ka, % | 55.6 (19.6) | 55.2 (22.1–67.2) |
| Tlag, % | 81.8 (74.4) | 74.1 (28.5–164.0) |
| Residual variability | ||
| Proportional error, % | 20.3 (29.6) | 20.0 (6.9–25.6) |
| Additive error, μg/L | 12.6 (62.8) | 12.6 (2.5–24.5) |