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HPLC-UV chromatograms of rat plasma. (A) rat plasma blank, (B) rat plasma spiked with sinomenine at its LOQ (0.1 μg/mL) and (C) plasma collected for 20 min after a 30 mg/kg ip dose of sinomenine in rats. The retention times of sinomenine and chloramphenicol were 5.66 min and 10.48 min, respectively.
