Table 1. The pharmacokinetic parameters of sinomenine in plasma and brain after a single ip dose of 30 mg/kg in rats.
| Pharmacokinetic parameters | Plasma | Brain | |
|---|---|---|---|
| Tmax | min | 10.0±2.6 | 15.0±3.7 |
| Cmax | mg/L | 154.12±25.56 | 1.23±0.25 |
| AUC(0–t) | mg/L·min | 2037.9±504.5 | 35.9±11.5 |
| AUC(0–∞) | mg/L·min | 2059.8±541.9 | 36.8±10.8 |
| t1/2α | min | 2.7±0.7 | 2.9±0.8 |
| t1/2β | min | 62.6±19.4 | 8.7±2.6 |
| t1/2Ka | min | 1.0±0.3 | 1.5±0.4 |
| CL/F | L/min/kg | 0.015±0.034 | 0.815±0.205 |
| V1/F | L/kg | 0.021±0.06 | 3.238±0.989 |
| MRT(0-t) | min | 30.1±8.9 | 38.8±11.5 |
Tmax: Time to reach maximum plasma concentration; Cmax: Maximum plasma concentration; AUC(0–t): Area under the concentration-time curve from zero up to a definite time t; AUC(0–∞): Area under the concentration–time curve from zero up to infinite time; t1/2β: Half-life of elimination phase; t1/2α: Half-life of distribution phase; t1/2Ka: Half-life of absorption phase; V1/F: Volume of distribution; CL/F: Total clearance; MRT: Mean residence time. Data are expressed as mean±SD.