Skip to main content
. 2010 Nov 5;31(11):1431–1437. doi: 10.1038/aps.2010.136

Figure 2.

Figure 2

A: Effect of morphine withdrawal on extinction of cued fear memory in WT and HDC-KO mice. Each group (n=8−11) received four fear extinction sessions on days 8–11 after the last morphine injection. bP<0.05, cP<0.01 vs saline-treated mice with the same genotype during the same extinction session; eP<0.05, fP<0.01 vs the group receiving the same treatment, compared between genotypes. KO: HDC-KO. B: Effect of injection of histamine (icv, 5 μg/mouse) 10 min before extinction sessions on extinction of cued fear memory in HDC-KO mice (n=8−9). bP<0.05 vs saline (icv)-treated morphine withdrawal group during the same extinction session.