Fig. 2.

Photosensitivity in pirfenidone-treated patients. a Patient 1: mild photosensitivity after 8 h driving. The patient had been receiving treatment with pirfenidone for 7 days. The patient presented with erythema localized to the more photoexposed areas of the hands. He had previously followed advice regarding photoprotection. On the day in question, he used a broad-spectrum SPF50+ sunscreen in the morning before sun exposure, but did not repeat the application. b Patient 2: moderate photosensitivity after 14 days pirfenidone treatment. The patient presented with erythema and peeling, mainly on the hands and face. Patient had omitted to apply sunscreen protection. c Patient 2: the same patient improved following 7 days of topical treatment (silver sulfadiazine), sunscreen protection, and pirfenidone dose reduction. The patients and treating physicians provided permission for the use of these images. SPF sun protection factor