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SB-399885 dose-dependently reduced food intake. 0.9% saline (white bar) or SB-399885 at doses of 1 (light grey bar) or 2 (black bar) mg/kg, i.p. was administered at the onset of the dark cycle and food intake measured over the next 2 h in rats. Data are presented as mean ± S.E.M. Statistics, one way ANOVA, F2,18 = 9.35, p = 0.016. **p < 0.01 compared to saline treatment.
