TABLE 2.
Summary of mutant phenotypes
| Group no. | Location(s) of CA changes | Relative infectivity in monkey cells compared to wt | Relative ability to compete for restricting factors in monkey cells compared to wt | Effect of CspA on infectivity in HeLa cells |
|---|---|---|---|---|
| 1 | CypA-binding loop and Ser149 (phosphorylation site) | Increase | Decrease | Increase or no change |
| 2 | Helix 3/6 ridge | Increase | Increase | Decrease |