Author response table 2.
The table was downloaded from the GenAge database and shows D. melanogaster genes whose homologs affect C. elegans and S. cerevisiae lifespans. We asked if gene expression differences as function of age were significant for these genes. We find that there is a good correlation as indicated by significant age-associated p values (highlighted cells).
| entrez_id | gene_id | model organism from | model organism gene symbol | model organism gene entrez_id | age-assoc p val. (Control diet) | age-assoc p val. (DR diet) |
|---|---|---|---|---|---|---|
| 37068 | FBgn0001222 | Caenorhabditis elegans | hsf-1 | 173078 | 0.208232323 | 0.014228222 |
| 32780 | FBgn0003380 | Caenorhabditis elegans | shk-1 | 174536 | 0.004195376 | 0.058999312 |
| 33379 | FBgn0003557 | Caenorhabditis elegans | wwp-1 | 171647 | 0.142217352 | 0.130634649 |
| 42549 | FBgn0013984 | Caenorhabditis elegans | daf-2 | 175410 | 0.349618864 | 0.011412462 |
| 42446 | FBgn0015279 | Caenorhabditis elegans | age-1 | 174762 | 0.664739688 | 1.19E-05 |
| 43856 | FBgn0015624 | Caenorhabditis elegans | cbp-1 | 176380 | 0.335702205 | 0.000305516 |
| 33025 | FBgn0015789 | Caenorhabditis elegans | rab-10 | 266836 | 2.50E-05 | 0.002107404 |
| 37546 | FBgn0020307 | Caenorhabditis elegans | dve-1 | 180398 | 0.951050741 | 0.022711332 |
| 47396 | FBgn0021796 | Caenorhabditis elegans | let-363 | 172167 | 0.011455499 | 0.030110581 |
| 43904 | FBgn0023169 | Caenorhabditis elegans | aak-2 | 181727 | 0.443564781 | 0.230111778 |
| 37035 | FBgn0026316 | Caenorhabditis elegans | ubc-18 | 175985 | 0.387612879 | 0.458766044 |
| 44007 | FBgn0029502 | Caenorhabditis elegans | clk-1 | 175729 | 0.604169327 | 4.28E-05 |
| 31443 | FBgn0029752 | Caenorhabditis elegans | trx-1 | 181863 | 0.434362398 | 0.30278161 |
| 32864 | FBgn0030954 | Caenorhabditis elegans | ckr-1 | 188774 | 0.839828486 | 0.067135437 |
| 32864 | FBgn0030954 | Caenorhabditis elegans | ckr-2 | 175341 | 0.839828486 | 0.067135437 |
| 37141 | FBgn0034366 | Caenorhabditis elegans | atg-7 | 178005 | 0.521877961 | 0.162316499 |
| 42358 | FBgn0038736 | Caenorhabditis elegans | ire-1 | 174305 | 0.004739753 | 2.99E-05 |
| 117332 | FBgn0041191 | Caenorhabditis elegans | rheb-1 | 176327 | 2.57E-10 | 0.002436925 |
| 42162 | FBgn0003499 | Saccharomyces cerevisiae | MSN4 | 853803 | 0.302140588 | 0.092952911 |
| 41311 | FBgn0011768 | Saccharomyces cerevisiae | SFA1 | 851386 | 0.161108282 | 0.021733851 |
| 33418 | FBgn0014010 | Saccharomyces cerevisiae | VPS21 | 854256 | 0.364851406 | 0.001462461 |
| 42036 | FBgn0015230 | Saccharomyces cerevisiae | HXT17 | 855809 | 0.878817736 | 0.470480109 |
| 42841 | FBgn0015795 | Saccharomyces cerevisiae | YPT7 | 855012 | 0.140249034 | 0.00372342 |
| 38565 | FBgn0015805 | Saccharomyces cerevisiae | RPD3 | 855386 | 0.481810547 | 0.216011826 |
| 38654 | FBgn0015806 | Saccharomyces cerevisiae | SCH9 | 856612 | 0.697957982 | 0.725796412 |
| 47396 | FBgn0021796 | Saccharomyces cerevisiae | TOR1 | 853529 | 0.011455499 | 0.030110581 |
| 47611 | FBgn0022160 | Saccharomyces cerevisiae | GUT2 | 854651 | 0.023200204 | 0.021014678 |
| 45706 | FBgn0023541 | Saccharomyces cerevisiae | ERG5 | 855029 | 0.005058412 | 0.003531191 |
| 44098 | FBgn0024194 | Saccharomyces cerevisiae | GUP1 | 852796 | 0.000164407 | 0.004031428 |
| 31410 | FBgn0025679 | Saccharomyces cerevisiae | MSN2 | 855053 | 0.323927221 | 0.694183066 |
| 32768 | FBgn0030876 | Saccharomyces cerevisiae | SRX1 | 853776 | 3.16E-05 | 0.279799695 |
| 33626 | FBgn0031589 | Saccharomyces cerevisiae | NPT1 | 854384 | 0.068625175 | 0.485137597 |
| 33837 | FBgn0031759 | Saccharomyces cerevisiae | GIS1 | 851670 | 0.655929353 | 0.163585059 |
| 34021 | FBgn0031912 | Saccharomyces cerevisiae | LAT1 | 855653 | 0.057376425 | 5.00E-07 |
| 37581 | FBgn0034744 | Saccharomyces cerevisiae | VPS20 | 855101 | 0.032323885 | 6.08E-05 |
| 38612 | FBgn0035600 | Saccharomyces cerevisiae | CYT1 | 854231 | 0.082518654 | 1.92E-08 |
| 38735 | FBgn0035704 | Saccharomyces cerevisiae | VPS8 | 851261 | 0.409695812 | 0.10467572 |
| 41071 | FBgn0037647 | Saccharomyces cerevisiae | GTR1 | 854918 | 0.440417904 | 0.031441517 |
| 41210 | FBgn0037761 | Saccharomyces cerevisiae | SUR4 | 851087 | 0.121178495 | 0.047327998 |
| 42185 | FBgn0038587 | Saccharomyces cerevisiae | MDH1 | 853777 | 0.201852989 | 0.005025531 |
| 53578 | FBgn0040309 | Saccharomyces cerevisiae | TSA1 | 854980 | 0.831741497 | 0.000946166 |
| 53581 | FBgn0040319 | Saccharomyces cerevisiae | GSH1 | 853344 | 0.356515036 | 0.174517354 |
| 38753 | FBgn0041194 | Saccharomyces cerevisiae | ADE4 | 855346 | 8.21E-06 | 2.59E-07 |
| 43191 | FBgn0042710 | Saccharomyces cerevisiae | HXK2 | 852639 | 0.367984828 | 0.002632023 |
| 42348 | FBgn0051216 | Saccharomyces cerevisiae | PNC1 | 852846 | 0.052873779 | 0.095056643 |
| 32097 | FBgn0052666 | Saccharomyces cerevisiae | PKH2 | 854053 | 0.204555882 | 0.408827494 |
| 42850 | #N/A | Caenorhabditis elegans | bec-1 | 177345 | not in the dataset | not in the dataset |
| 40633 | #N/A | Caenorhabditis elegans | egl-9 | 179461 | not in the dataset | not in the dataset |
| 41612 | #N/A | Caenorhabditis elegans | hif-1 | 180359 | not in the dataset | not in the dataset |
| 48552 | #N/A | Caenorhabditis elegans | sams-1 | 181370 | not in the dataset | not in the dataset |
| 41675 | #N/A | Caenorhabditis elegans | smk-1 | 179243 | not in the dataset | not in the dataset |
| 39454 | #N/A | Caenorhabditis elegans | unc-51 | 180311 | not in the dataset | not in the dataset |
| 37733 | #N/A | Caenorhabditis elegans | vps-34 | 172280 | not in the dataset | not in the dataset |
| 31618 | #N/A | Saccharomyces cerevisiae | CDC25 | 851019 | not in the dataset | not in the dataset |
| 44297 | #N/A | Saccharomyces cerevisiae | DAP2 | 856423 | not in the dataset | not in the dataset |
| 35494 | #N/A | Saccharomyces cerevisiae | FET3 | 855080 | not in the dataset | not in the dataset |
| 3771854 | #N/A | Saccharomyces cerevisiae | HHF1 | 852294 | not in the dataset | not in the dataset |
| 42414 | #N/A | Saccharomyces cerevisiae | HST2 | 856092 | not in the dataset | not in the dataset |
| 326219 | #N/A | Saccharomyces cerevisiae | LCB4 | 854342 | not in the dataset | not in the dataset |
| 318252 | #N/A | Saccharomyces cerevisiae | NFU1 | 853826 | not in the dataset | not in the dataset |
| 35988 | #N/A | Saccharomyces cerevisiae | RPL31A | 851484 | not in the dataset | not in the dataset |
| 42850 | #N/A | Saccharomyces cerevisiae | VPS30 | 855983 | not in the dataset | not in the dataset |