Table 2.
Characteristics of ILD patients requiring mechanical ventilation who did and did not survive to hospital discharge•
| Variables | Survivors (n= 44) | Non-survivors (n=50) | P value |
|---|---|---|---|
|
| |||
| Sex, no. (%) | |||
| Male | 21 (48%) | 29 (58%) | 0.319 |
| Female | 23 (52%) | 21 (42%) | |
|
| |||
| Age, year | |||
| Median (range) | 71 (57 to 78) | 74 (67 to 79) | 0.122 |
|
| |||
| Duration from diagnosis to ICU admission, months | 18 (0.31 to 49) | 2 (0.10 to 40) | 0.248 |
|
| |||
| IPF | 12 (27%) | 18 (36%) | 0.507 |
| Non-IPF | 31 (70%) | 32 (64%) | |
|
| |||
| PFTs (% predicted) | |||
| FEV1 | 60 (46 to 73) | 62 (44 to 75) | 0.991 |
| FVC | 62 (53 to 76) | 62 (47 to 74) | 0.551 |
| TLC | 73 (61 to 84) | 67 (52 to 84) | 0.572 |
| DLCO | 47 (38 to 66) | 41 (33 to 55) | 0.113 |
|
| |||
| Post-operative respiratory failure | 29 (71%) | 12 (29%) | <0.001 |
|
| |||
| Systolic pulmonary artery pressure, mmHg | 46 (33 to 59) | 53 (36 to 66) | 0.062 |
|
| |||
| Ejection fraction, % | 60 (45 to 60) | 60 (52 to 65) | 0.918 |
|
| |||
| ICU high dose steroids | |||
| 13 (29%) | 16 (32%) | 0.797 NS |
|
| IPF | 4 (31%) | 5 (31%) | |
| Non-IPF | 9 (69%) | 11(69%) | |
|
| |||
| PaCO2, mmHg | 39 (37 to 44) | 41 (36 to 47) | 0.289 |
| PaO2/FIO2 ratio | 252 (158 to 388) | 117 (71 to 182) | <0.001 |
| NIPPV before intubation | 5 (11%) | 16 (32%) | 0.014 |
| Vt mL/kg PBW | 8 (7 to 10) | 7 (6 to 9) | 0.023 |
| Set respiratory rate | 11 (8 to 13) | 18 (10 to 23) | <0.001 |
| PEEP, cmH2O | 5 (5 to 6) | 9.5 (5 to 10) | 0.001 |
| FIO2 | 0.4 (0.4 to 0.6) | 0.6 (0.5 to 0.8) | <0.001 |
| Mean airway pressure, cmH2O | 10 (8 to 12) | 14 (10 to 18) | 0.001 |
| Peak airway pressure, cmH2O | 24 (22 to 29) | 30 (25 to 33) | 0.001 |
| Plateau pressure, cmH2O, n=45 | 21 (16 to 25) | 33(25 to 39) | 0.001 |
|
| |||
| APACHE III score | 57 (47 to 69) | 78 (61 to 96) | <0.001 |
| ICU predicted mortality | 6 (2 to 12) | 18 (7 to 36) | <0.001 |
| Hospital predicted mortality | 9 (5 to 21) | 37 (16 to 59) | 0.001 |
|
| |||
| ICU length of stay, days | 2 (1 to 8) | 5 (2 to 10) | 0.016 |
| Hospital length of stay, days | 10 (6 to 16) | 11 (7 to 21) | 0.543 |
Data are represented as median (interquartile range) and number (percentage). IPF, idiopathic pulmonary fibrosis; ICU, intensive care unit; TLC, total lung capacity; DLCO, diffuse capacity of lungs for carbon monoxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; PaO2, partial pressure of oxygen, FIO2, fraction of inspired oxygen; SaO2, arterial oxygen saturation; PaCO2, partial pressure of carbon dioxide; PEEP, positive end expiratory pressure; NIPPV, noninvasive positive pressure ventilation; Vt, tidal volume; PBW, predicted body weight; PFT, pulmonary function test; ARDS, acute respiratory distress syndrome; APACHE, Acute Physiology and Chronic Health Evaluation.