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. 2014 Apr 22;2:46. doi: 10.1186/2051-5960-2-46

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Copyright © 2014 Leinonen et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Examples of abnormal and normal [¹⁸F]flutemetamol positron emission tomography (PET) and corresponding magnetic resonance (MR) or computed tomography (CT) imaging and histopathology. Panel a) [¹⁸F]Flutemetamol PET imaging correlates with histopathology (Study D). Amyloid plaques were determined in biopsy samples by 4G8 imunohistochemistry (IHC). Neuritic plaques were identified in serial sections using a modified Bielschowsky silver stain. Panel b) [¹⁸F]Flutemetamol PET images were obtained either retrospectively after biopsy (Studies A and C) or prospectively before biopsy (Studies B and D). Small cortical biopsies were taken during shunt placement and histopathology was correlated to standard uptake value ratio (SUVR) measures in volumes of interest (VOIs) either ipsilateral or contralateral to the site of biopsy.