Table 10.

Sensitivity, specificity, and exact 95% CI for each SUVR type/pathology SoT combination in retrospective vs. prospective studies for all 4 studies combined

	Cerebellum REF			Pons REF
Pathology SoT	Ipsilateral	Contralateral	Composite	Ipsilateral	Contralateral	Composite
4G8
Retrospective
Sensitivity (95% CI)	1.0000 (0.3976, 1.0000)	1.0000 (0.3976, 1.0000)	0.5000 (0.0676, 0.9324)	1.0000 (0.3976, 1.0000)	0.7500 (0.1941, 0.9937)	0.7500 (0.1941, 0.9937)
Specificity (95% CI)	0.6000 (0.3605, 0.8088)	0.7500 (0.5090, 0.9134)	0.9000 (0.6830, 0.9877)	0.4762 (0.2571, 0.7022)	0.6667 ()0.4303, 0.8541	0.6667 (0.4303, 0.8541)
Sum (sensitivity + specificity)	1.6000	1.7500	1.4000	1.4762	1.4167	1.4167
Prospective
Sensitivity (95% CI)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)	0.8000 (0.2836, 0.9949)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)
Specificity (95% CI)	0.6471 (0.3833, 0.8579)	0.5882 (0.3292, 0.8156)	0.8235 (0.5657, 0.9620)	0.5294 (0.2781, 0.7702)	0.6471 (0.3833, 0.8579)	0.5882 (0.3292, 0.8156)
Sum (sensitivity + specificity)	1.6471	1.5882	1.6235	1.5294	1.6471	1.5882
Bielschowsky
Retrospective
Sensitivity (95% CI)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)	1.0000 (0.4782, 1.0000)
Specificity (95% CI)	0.8750 (0.6165, 0.9845)	0.8750 (0.6165, 0.9845)	0.9375 (0.6977, 0.9984)	0.7647 (0.5010, 0.9319)	0.8824 (0.6356, 0.9854)	0.8824 (0.6356, 0.9854)
Sum (sensitivity + specificity)	1.8750	1.8750	1.9375	1.7647	1.8824	1.8824
Prospective
Sensitivity (95% CI)	1.0000 (0.2924, 1.0000)	1.0000 (0.2924, 1.0000)	1.0000 (0.2924, 1.0000)	1.0000 (0.2924, 1.0000)	1.0000 (0.2924, 1.0000)	1.0000 (0.2924, 1.0000)
Specificity (95% CI)	0.9091 (0.5872, 0.9977)	0.9091 (0.5872, 0.9977)	0.9091 (0.5872, 0.9977)	0.9091 (0.5872, 0.9977)	1.0000 (0.7151, 1.000)	0.8182 (0.4822, 0.9772)
Sum (sensitivity + specificity)	1.9091	1.9091	1.9091	1.9091	2.0000	1.8182
Thioflavin S
Retrospective
Sensitivity (95% CI)	0.8571 (0.4213, 0.9964)	0.8571 (0.4213, 0.9964)	1.0000 (0.5904, 1.0000)	0.8571 (0.4213, 0.9964)	0.8571 (0.4213, 0.9964)	0.8571 (0.4213, 0.9964)
Specificity (95% CI)	1.0000 (0.8235, 1.0000)	0.9474 (0.7397, 0.9987)	0.8947 (0.6686, 0.9870)	0.7000 (0.4572, 0.8811)	0.9000 (0.6830, 0.9877)	0.9000 (0.6830, 0.9877)
Sum (sensitivity + specificity)	1.8571	1.8045	1.8947	1.5571	1.7571	1.7571
Prospective
Sensitivity (95% CI)	0.5000 (0.0126, 0.9874)	1.0000 (0.1581, 1.0000)	1.0000 (0.1581, 1.0000)	1.0000 (0.1581, 1.0000)	1.0000 (0.1581, 1.0000)	1.0000 (0.1581, 1.0000)
Specificity (95% CI)	0.9231 (0.6397, 0.9981)	0.8462 (0.5455, 0.9808)	0.7692 (0.4619, 0.9496)	0.8462 (0.5455, 0.9808)	0.9231 (0.6397, 0.9981)	0.7692 (0.4619, 0.9496)
Sum (sensitivity + specificity)	1.4231	1.8462	1.7692	1.8462	1.9231	1.7692
Overall pathology
Retrospective
Sensitivity (95% CI)	1.0000 (0.5407, 1.0000)	1.0000 (0.5407, 1.0000)	1.0000 (0.5407, 1.0000)	1.0000 (0.5407, 1.0000)	1.0000 (0.5407, 1.0000)	1.0000 (0.5407, 1.0000)
Specificity (95% CI)	1.0000 (0.8316, 1.000)	0.9500 (0.7513, 9987)	1.0000 (0.8316, 1.0000)	0.8095 (0.5809, 0.9455)	0.8571 (0.6366, 0.9695)	1.0000 (0.8389, 1.000)
Sum (sensitivity + specificity)	2.0000	1.9500	2.0000	1.8095	1.8571	2.0000
Prospective
Sensitivity (95% CI)	0.8750 (0.4735, 0.9968)	1.0000 (0.6306, 1.0000)	1.0000 (0.6306, 1.0000)	0.8750 (0.4735, 0.9968)	1.0000 (0.6306, 1.0000)	0.8750 (0.4735, 0.9968)
Specificity (95% CI)	1.0000 (0.7684, 1.000)	1.0000 (0.7684, 1.0000)	1.0000 (0.7684, 1.0000)	0.9286 (0.6613, 0.9982)	0.9286 (0.6613, 0.9982)	1.0000 (0.7684, 1.0000)
Sum (sensitivity + specificity)	1.8750	2.0000	2.0000	1.8036	1.9286	1.8750

REF = PET imaging brain reference region; SoT = standard of truth, SUVR = standard uptake value ratio. Refer to [32] for a discussion of agreement between readers.