Table 2.
Summary of methods by study: MRI and [ 18 F]flutemetamol PET image acquisition
| Study A | Study B | Study C | Study D | |
|---|---|---|---|---|
|
Injected activity/dose of [
18
F]flutemetamol (MBq) |
Approximately 185; range, 111 to 197 |
Mean 200; range, 178 to 252 |
Mean (SD, 178 (3.4); range, 174 to 185 |
Mean 176; range, 169 to 184 |
|
MRI image equipment |
3 T Siemens Trio whole-body scanner (Siemens, Erlangen Germany) equipped with a product 8-channel array coil |
Siemens 3 T TRIO (Milwaukee, WI, USA) |
1.5 T Philips MRI scanner Gyroscan Intera CV Nova Dual system (Philips Medical Systems, Best, The Netherlands) |
|
|
PET imaging equipment |
Allegro whole-body PET scanner (Philips, Andover, MA, USA) obtained in a single FOV |
GE Advance PET scanner (GE Medical Systems, Milwaukee, WI, USA) in 3D modes with a 14.875-cm axial FOV obtained in a single FOV |
ECAT EXACT HR + scanner (Siemens-CTI, Knoxville, TN, USA) |
|
| Reconstruction | Reconstructed by a 3-dimensional row-action maximum likelihood algorithm. Approximate spatial resolution was 6 mm. | Reconstructed to 35 transaxial images of 128 x 128 voxels by a back-projection algorithm using manufacturer-provided software correcting for attenuation, scatter, and dead time. Resolution was approximately 6 mm at full width at half maximum. | Not stated. | Not stated. |
FOV = field of view; MRI = magnetic resonance imaging; PET = positron emission tomography.
Note: Information in this table was extracted from the original study publications (refer to text) and supplemented with data from the clinical trial submission documents.