Table 6.
ROC AUC, Youden index, and Optimal SUVR thresholds by SUVR type and pathology SoT for all 4 studies combined
|
Pathology standard of truth |
|
|
|
|
|---|---|---|---|---|
|
SUVR type |
|
|
|
|
| SUVR brain region | REF | ROC AUC | Maximal Youden index | SUVR cut-off criterion |
| 4G8 |
|
|
|
|
| Ipsilateral |
Cerebellum |
0.8544 |
0.6216 |
>1.25 |
| Contralateral |
Cerebellum |
0.8529 |
0.6757 |
>1.24 |
| Composite |
Cerebellum |
0.7508 |
0.5315 |
>1.79 |
| Ipsilateral |
Pons |
0.7763 |
0.5000 |
>0.42 |
| Contralateral |
Pons |
0.7853 |
0.5468 |
>0.44 |
| Composite |
Pons |
0.7583 |
0.5205 |
>0.45 |
| Bielschowsky |
|
|
|
|
| Ipsilateral |
Cerebellum |
0.9769 |
0.8889 |
>1.31 |
| Contralateral |
Cerebellum |
0.9769 |
0.8889 |
>1.31 |
| Composite |
Cerebellum |
0.9815 |
0.9259 |
>1.38 |
| Ipsilateral |
Pons |
0.9699 |
0.8214 |
>0.46 |
| Contralateral |
Pons |
0.9815 |
0.9286 |
>0.48 |
| Composite |
Pons |
0.9792 |
0.8571 |
>0.48 |
| Thioflavin S |
|
|
|
|
| Ipsilateral |
Cerebellum |
0.9288 |
0.7465 |
>1.62 |
| Contralateral |
Cerebellum |
0.9253 |
0.7951 |
>1.31 |
| Composite |
Cerebellum |
0.9462 |
0.8438 |
>1.34 |
| Ipsilateral |
Pons |
0.8767 |
0.6465 |
>0.46 |
| Contralateral |
Pons |
0.9132 |
0.7980 |
>0.48 |
| Composite |
Pons |
0.9236 |
0.7374 |
>0.5 |
| Overall pathology |
|
|
|
|
| Ipsilateral |
Cerebellum |
0.9916 |
0.9286 |
>1.5 |
| Contralateral |
Cerebellum |
0.9979 |
0.9706 |
>1.31 |
| Composite |
Cerebellum |
1.0000 |
1.0000 |
>1.46 |
| Ipsilateral |
Pons |
0.9433 |
0.7857 |
>0.472 |
| Contralateral |
Pons |
0.9842 |
0.8857 |
>0.479 |
| Composite | Pons | 0.9947 | 0.9286 | >0.53 |
AUC = area under the curve; REF = brain reference region; ROC = receiver-operator curve; SUVR = standard uptake value ratio; SoT = standard of truth; VOI = volume of interest.
Note: SUVR cut-off criterion is the SUVR value that maximizes the value of the Youden index. The SUVR cut-off value is the SUVR value above which lies a reading of abnormal and below or equal to which is a reading of normal.