Table 7.
Sensitivity and specificity and their exact 95% CIs for each SUVR type/pathology SoT combination for all 4 studies combined
| |
Cerebellum REF |
Pons REF |
||||
|---|---|---|---|---|---|---|
| Pathology SoT | Ipsilateral | Contralateral | Composite | Ipsilateral | Contralateral | Composite |
|
4G8 |
|
|
|
|
|
|
| Sensitivity (95% CI) |
1.0000 (0.6637, 1.0000) |
1.0000 (0.6637, 1.0000) |
0.6667 (0.2993, 0.9251) |
1.0000 (0.6637, 1.0000) |
0.8889 (0.5175, 0.9972) |
0.8889 (0.5175, 0.9972) |
| Specificity (95% CI) |
0.6216 (0.4476, 0.7754) |
0.6757 (0.5021, 0.8199) |
0.8649 (0.7123, 0.9546) |
0.5000 (0.3338, 0.6662) |
0.6579 (0.4865, 0.8037) |
0.6316 (0.4599, 0.7819) |
| Maximal sum (sensitivity + specificity) |
1.6216 |
1.6757 |
1.5316 |
1.5000 |
1.5468 |
1.5205 |
|
Bielschowsky |
|
|
|
|
|
|
| Sensitivity (95% CI) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
| Specificity (95% CI) |
0.8889 (0.7084, 0.9765) |
0.8889 (0.7084, 0.9765) |
0.9259 (0.7571, 0.9909) |
0.8214 (0.6311, 0.9394) |
0.9286 (0.7650, 0.9912) |
0.8571 (0.6733, 0.9597) |
| Maximal sum (sensitivity + specificity) |
1.8889 |
1.8889 |
1.9259 |
1.8214 |
1.9286 |
1.8571 |
|
Thioflavin S |
|
|
|
|
|
|
| Sensitivity (95% CI) |
0.7778 (0.3999, 0.9719) |
0.8889 (0.5175, 0.9972) |
1.0000 (0.6637, 1.0000) |
0.8889 (0.5175, 0.9972) |
0.8889 (0.5175, 0.9972) |
0.8889 (0.5175, 0.9972) |
| Specificity (95% CI) |
0.9688 (0.8378, 0.9992) |
0.9063 (0.7498, 0.9802) |
0.8438 (0.6721, 0.9472) |
0.7576 (0.5774, 0.8891) |
0.9091 (0.7567, 0.9808) |
0.8485 (0.6810, 0.9489) |
| Maximal sum (sensitivity + specificity) |
1.7466 |
1.7952 |
1.8438 |
1.6465 |
1.7980 |
1.7374 |
|
Overall pathology |
|
|
|
|
|
|
| Sensitivity (95% CI) |
0.9286 (0.6613, 0.9982) |
1.0000 (0.7684, 1.0000) |
1.0000 (0.7684, 1.0000) |
0.9286 (0.6613, 0.9982) |
1.0000 (0.7684, 1.0000) |
0.9286 (0.6613, 0.9982) |
| Specificity (95% CI) |
1.0000 (0.8972, 1.0000) |
0.9706 (0.8467, 0.9993) |
1.0000 (0.8972, 1.0000) |
0.8571 (0.6974, 0.9519) |
0.8857 (0.7326, 0.9680) |
1.0000 (0.9000, 1.0000) |
| Maximal sum (sensitivity + specificity) | 1.9286 | 1.9706 | 2.0000 | 1.7857 | 1.8857 | 1.9286 |
CI = confidence interval; REF = PET imaging brain reference region; SoT = standard of truth, SUVR = standard uptake value ratio.