Table 8.
Accuracy of [ 18 F]flutemetamol quantitative diagnosis and positive and negative predictive values by Aβ pathology SoT in the 4 studies combined
|
Pathology standard of truth |
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|
|
SUVR type |
|
SUVR/SoT, N (%) |
N |
(%) |
|||||
| Brain SUVR region | REF | TN n (%) | FN n (%) | FP n (%) | TP n (%) | Total | Accuracy a | PPV b | NPV c |
| 4G8% area |
|
|
|
|
|
|
|
|
|
| Ipsi |
C |
23 (62) |
0 (0) |
14 (38) |
9 (100) |
46 |
69.57 |
39.13 |
100.00 |
| Contra |
C |
25 (68) |
0 (0) |
12 (32) |
9 (100) |
46 |
73.91 |
42.86 |
100.00 |
| Comp |
C |
32 (86) |
3 (33) |
5 (14) |
6 (67) |
46 |
82.61 |
54.55 |
91.43 |
| Ipsi |
P |
19 (50) |
0 (0) |
19 (50) |
9 (100) |
47 |
59.57 |
32.14 |
100.00 |
| Contra |
P |
25 (66) |
1 (11) |
13 (34) |
8 (89) |
47 |
70.21 |
38.10 |
96.15 |
| Comp |
P |
24 (63) |
1 (11) |
14 (37) |
8 (89) |
47 |
68.09 |
36.36 |
96.00 |
| Bielschowsky silver plaque score |
|
|
|
|
|
|
|
|
|
| Ipsi |
C |
24 (89) |
0 (0) |
3 (11) |
8 (100) |
35 |
91.43 |
72.73 |
100.00 |
| Contra |
C |
24 (89) |
0 (0) |
3 (11) |
8 (100) |
35 |
91.43 |
72.73 |
100.00 |
| Comp |
C |
25 (93) |
0 (0) |
2 (7) |
8 (100) |
35 |
94.29 |
80.00 |
100.00 |
| Ipsi |
P |
23 (82) |
0 (0) |
5 (18) |
8 (100) |
36 |
86.11 |
61.54 |
100.00 |
| Contra |
P |
26 (93) |
0 (0) |
2 (7) |
8 (100) |
36 |
94.44 |
80.00 |
100.00 |
| Comp |
P |
24 (86) |
0 (0) |
4 (14) |
8 (100) |
36 |
88.89 |
66.67 |
100.00 |
| Thioflavin S plaque score |
|
|
|
|
|
|
|
|
|
| Ipsi |
C |
31 (97) |
2 (22) |
1 (3) |
7 (78) |
41 |
92.68 |
87.50 |
93.94 |
| Contra |
C |
29 (91) |
1 (11) |
3 (9) |
8 (89) |
41 |
90.24 |
72.73 |
96.67 |
| Comp |
C |
27 (84) |
0 (0) |
5 (16) |
9 (100) |
41 |
87.80 |
64.29 |
100.00 |
| Ipsi |
P |
25 (76) |
1 (11) |
8 (24) |
8 (89) |
42 |
78.57 |
50.00 |
96.15 |
| Contra |
P |
30 (91) |
1 (11) |
3 (9) |
8 (89) |
42 |
90.48 |
72.73 |
96.77 |
| Comp |
P |
28 (85) |
1 (11) |
5 (15) |
8 (89) |
42 |
85.71 |
61.54 |
96.55 |
| Overall pathology |
|
|
|
|
|
|
|
|
|
| Ipsi |
C |
34 (100) |
1 (7) |
0 (0) |
13 (93) |
48 |
97.92 |
100.00 |
97.14 |
| Contra |
C |
33 (97) |
0 (0) |
1 (3) |
14 (100) |
48 |
97.92 |
93.33 |
100.00 |
| Comp |
C |
34 (100) |
0 (0) |
0 (0) |
14 (100) |
48 |
100.00 |
100.00 |
100.00 |
| Ipsi |
P |
30 (86) |
1 (7) |
5 (14) |
13 (93) |
49 |
87.76 |
72.22 |
96.77 |
| Contra |
P |
31 (89) |
0 (0) |
4 (11) |
14 (100) |
49 |
91.84 |
77.78 |
100.00 |
| Comp | P | 35 (100) | 1 (7) | 0 (0) | 13 (93) | 49 | 97.96 | 100.00 | 97.22 |
C = cerebellum; Comp = composite; Contra = contralateral; FN = false negatives; FP = false positives; Ipsi = ipsilateral; N = number of patients; NPV = negative predictive value; P = pons; PPV = positive predictive value; REF = PET imaging brain reference region; ROC = receiver-operator curve; SoT = standard of truth; TN = true negatives; TP = true positives; SUVR = standard uptake value ratio.