Table 9.
Sensitivity, specificity, and exact 95% CIs for each image reading method (quantitative vs. majority BIE) by pathology SoT for all 4 studies combined
| |
Cerebellum REF |
Pons REF |
||||
|---|---|---|---|---|---|---|
| Pathology SoT | Ipsilateral | Contralateral | Composite | Ipsilateral | Contralateral | Composite |
|
4G8
|
|
|
|
|
|
|
| Quantitative (SUVR) |
|
|
|
|
|
|
| Sensitivity (95% CI) |
1.0000 (0.6637, 1.0000) |
1.0000 (0.6637, 1.0000) |
0.6667 (0.2993, 0.9251) |
1.0000 (0.6637, 1.0000) |
0.8889 (0.5175, 0.9972) |
0.8889 (0.5175, 0.9972) |
| Specificity (95% CI) |
0.6216* (0.4476, 0.7754) |
0.6757 (0.5021, 0.8199) |
0.8649 (0.7123, 0.9546) |
0.5000* (0.3338, 0.6662) |
0.6579* (0.4865, 0.8037) |
0.6316 a (0.4599, 0.7819) |
| Sum (sensitivity + specificity) |
1.6216 |
1.6757 |
1.5316 |
1.5000 |
1.5468 |
1.5205 |
| BIE |
|
|
|
|
|
|
| Sensitivity (95% CI) |
0.6667 (0.2993, 0.9251) |
0.6667 (0.2993, 0.9251) |
0.6667 (0.2993, 0.9251) |
0.6667 (0.2993, 0.9251) |
0.6667 (0.2993, 0.9251) |
0.6667 (0.2993, 0.9251) |
| Specificity (95% CI) |
0.8108* (0.6484, 0.9204) |
0.8108 (0.6484, 0.9204) |
0.8108 (0.6484, 0.9204) |
0.8158* (0.6567, 0.9226) |
0.8158* (0.6567, 0.9226) |
0.8158* (0.6567, 0.9226) |
| Sum (sensitivity + specificity) |
1.4775 |
1.4825 |
1.4775 |
1.4825 |
1.4825 |
1.4825 |
|
Bielschowsky
|
|
|
|
|
|
|
| Quantitative (SUVR) |
|
|
|
|
|
|
| Sensitivity (95% CI) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
| Specificity (95% CI) |
0.8889 (0.7084, 0.9765) |
0.8889 (0.7084, 0.9765) |
0.9259 (0.7571, 0.9909) |
0.8214 (6311, 9394) |
0.9286 (0.7650, 0.9912) |
0.8571 (0.6733, 0.9597) |
| Sum (sensitivity + specificity) |
1.8889 |
1.8889 |
1.9259 |
1.8214 |
1.9286 |
1.8571 |
| BIE |
|
|
|
|
|
|
| Sensitivity (95% CI) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
1.0000 (0.6306, 1.0000) |
| Specificity (95% CI) |
0.9630 (0.8103, 0.9991) |
0.9630 (0.8103, 0.9991) |
0.9630 (0.8103, 0.9991) |
0.9643 (0.9165, 0.9991) |
0.9643 (0.8165, 0.9991) |
0.9643 (0.8165, 0.9991) |
| Sum (sensitivity + specificity) |
1.9630 |
1.9630 |
1.9630 |
1.9643 |
1.9643 |
1.9643 |
|
Thioflavin S
|
|
|
|
|
|
|
| Quantitative (SUVR) |
|
|
|
|
|
|
| Sensitivity (95% CI) |
0.7778 (0.3999, 0.9719) |
0.8889 (0.5175, 0.9972) |
1.0000 (0.6637, 1.0000) |
0.8889 (0.5175, 0.9972) |
0.8889 (0.5175, 0.9972) |
0.8889 (0.5175, 0.9972) |
| Specificity (95% CI) |
0.9688 (0.8378, 0.9992) |
0.9063 (0.7498, 0.9802) |
0.8438 (0.6721, 0.9472) |
0.7576* (0.5774, 0.8891) |
0.9091 (0.7567, 0.9808) |
0.8485 (0.6810, 0.9489) |
| Sum (sensitivity + specificity) |
1.7466 |
1.7952 |
1.8438 |
1.6465 |
1.7980 |
1.7374 |
| BIE |
|
|
|
|
|
|
| Sensitivity (95% CI) |
0.7778 (0.3999, 0.9719) |
0.7778 (0.3999, 0.9719) |
0.7778 (0.3999, 0.9719) |
0.7778 (0.3999, 0.9719) |
0.7778 (0.3999, 0.9719) |
0.7778 (0.3999, 0.9719) |
| Specificity (95% CI) |
0.9375 (0.7919, 0.9923) |
0.9375 (0.7919, 0.9923) |
0.9375 (0.7919, 0.9923) |
0.9394* (0.7977, 0.9926) |
0.9394 (0.7977, 0.9926) |
0.9394 (0.7977, 0.9926) |
| Sum (sensitivity + specificity) |
1.7153 |
1.7153 |
1.7153 |
1.7172 |
1.7172 |
1.7172 |
|
Overall pathology
|
|
|
|
|
|
|
| Quantitative (SUVR) |
|
|
|
|
|
|
| Sensitivity (95% CI) |
0.9286 (0.6613, 0.9982) |
1.0000 (0.7684, 1.0000) |
1.0000 (0.7684, 1.0000) |
0.9286 (0.6613, 0.9982) |
1.0000 (0.7684, 1.0000) |
0.9286 (0.6613, 0.9982) |
| Specificity (95% CI) |
1.0000 (0.8972, 0.1.000) |
0.9706 (0.8467, 0.9993) |
1.0000 (0.8972, 1.0000) |
0.8571 (0.6974, 0.9519) |
0.8857 (0.7326, 0.9680) |
1.0000 (0.9000, 1.0000) |
| Sum (sensitivity + specificity) |
1.9286 |
1.9706 |
2.000 |
1.7857 |
1.8857 |
1.9286 |
| BIE |
|
|
|
|
|
|
| Sensitivity (95% CI) |
0.9286 (0.6613, 0.9982) |
0.9286 (0.6613, 0.9982) |
0.9286 (0.6613, 0.9982) |
0.9286 (0.6613, 0.9982) |
0.9286 (0.6613, 0.9982) |
0.9286 (0.6613, 0.9982) |
| Specificity (95% CI) |
1.0000 (0.8972, 1.0000) |
1.0000 (0.8972, 1.0000) |
1.0000 (0.8972, 1.0000) |
1.0000 (0.9000, 1.0000) |
1.0000 (0.9000, 1.0000) |
1.0000 (0.9000, 1.0000) |
| Sum (sensitivity + specificity) | 1.9286 | 1.9286 | 1.9286 | 1.9286 | 1.9286 | 1.9286 |
BIE = blinded image examination majority read; CI = confidence interval; REF = PET imaging brain reference region; SoT = standard of truth, SUVR = standard uptake value ratio. Refer to [32] for a discussion of agreement between readers.
*Specificity was higher for BIE than for quantitative SUVR (p <0.05).