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. 2014 Apr 7;11(6):554–563. doi: 10.7150/ijms.8407

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Reduced synergistic transcriptional activation by mutant NKX2-5 and GATA4. The synergistic activation by E21Q-mutant NKX2-5 and GATA4 was significantly reduced compared with that by wild-type NKX2-5 and GATA4. The E21Q-mutant NKX2-5 had significantly reduced synergistic effect while the T180A-mutant had no synergistic effect on GATA4-induced activation of the atrial natriuretic factor promoter. Experiments were performed in triplicate, and mean and standard deviations are shown. * represents p < 0.01 and ** represents p < 0.001, when compared with wild-type NKX2-5 and GATA4.