FIG. 1.

Protection of ME-180 cells from infection by HSV-1 and HSV-2 (MTT assay). Peptides (50 μg/ml) and viruses were coincubated for 2 h, before being added to target cell monolayers that also contained 50 μg of peptide/ml. After incubation at 37°C for 72 h, cytotoxicity was measured with a kit. The bars (black, HSV-1; gray, HSV-2) represent means ± standard errors of the means of two to five experiments with each peptide. Asterisks identify the peptides whose activities against HSV-1 and HSV-2 differed significantly (P < 0.001). Group A and group B peptides are further described in the text.