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Protection against HSV-1 and HSV-2. The most active peptides against HSV-1 and HSV-2 were RTD 3, retrocyclin 1 (RC 100), and retrocyclin 2 (RC 100b). Each peptide (various concentrations) was incubated with HSV-1 or HSV-2 for 2 h and added to ME-180 cell monolayers with the same concentration of peptide. After a 24-h incubation, aliquots were harvested for plaque counting.
