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Correlation between the binding of θ defensins to immobilized gB2 and protective activity against HSV-2
| θ defensin peptide | Net charge | Kon (104 M−1 s−1) | Koff (10−3 s−1) | Kd (nM) | Activity vs:
|
|
|---|---|---|---|---|---|---|
| HSV-2 | HSV-1 | |||||
| RTD 1 | +5 | 0.196 | 8.33 | 4,240.0 | None | None |
| RTD 2 | +6 | 5.25 | 7.06 | 134.0 | Moderate | None |
| RTD 3 | +4 | 5.36 | 9.33 | 174.0 | High | High |
| Retrocyclin 1 | +4 | 6.76 | 9.58 | 142.0 | Moderate | High |
| Retrocyclin 2 | +5 | 22.9 | 3.05 | 13.3 | High | High |
| Retrocyclin 3 | +6 | 3.47 | 10.2 | 295.0 | None | None |
