Table 1.
Time | Group | n | LVSV mL | ΔLVSV mL | LVDV mL | ΔLVDV mL | EF% | ΔEF% |
---|---|---|---|---|---|---|---|---|
Before administration | Sham | 4 | 6.51 ± 2.40 | — | 26.70 ± 8.27 | — | 76.93 ± 4.22 | — |
Model | 6 | 20.05 ± 2.08* | — | 43.18 ± 4.08 | — | 51.85 ± 7.50** | — | |
Digoxin | 6 | 27.53 ± 12.97** | — | 51.73 ± 21.38* | — | 47.90 ± 14.07** | — | |
QSYQ | 6 | 29.30 ± 7.93** | — | 46.77 ± 11.41* | — | 36.90 ± 12.70** | — | |
| ||||||||
2 weeks after administration | Sham | 4 | 5.76 ± 1.83 | −0.75 ± 0.57 | 25.20 ± 4.06 | −1.50 ± 12.33 | 77.68 ± 3.33 | 0.75 ± 0.89 |
Model | 6 | 20.00 ± 5.04* | −0.05 ± 2.963 | 39.40 ± 12.15 | −3.78 ± 8.07 | 46.05 ± 7.55** | −5.80 ± 0.05 | |
Digoxin | 6 | 20.67 ± 9.67* | −6.86 ± 3.30∗▵▵ | 46.00 ± 15.30* | −5.73 ± 6.08 | 56.78 ± 15.04** | 8.88 ± 0.97∗∗▵▵ | |
QSYQ | 6 | 25.53 ± 5.78* | −3.77 ± 2.15 | 47.97 ± 7.82 | 1.20 ± 3.59 | 47.13 ± 3.99** | 10.23 ± 8.71▵▵▴ | |
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4 weeks after administration | Sham group | 4 | 6.77 ± 2.85 | 0.26 ± 0.45 | 30.63 ± 7.12 | 3.93 ± 15.39 | 79.05 ± 5.61 | 10.23 ± 9.78 |
Model group | 6 | 22.85 ± 5.31** | 2.80 ± 3.23 | 50.08 ± 11.76* | 6.90 ± 7.68 | 50.34 ± 7.44** | −1.51 ± 0.06 | |
Digoxin group | 6 | 20.83 ± 9.22* | −6.70 ± 3.75∗▵▵ | 44.95 ± 12.43 | −6.78 ± 8.95∗∗▵▵ | 55.23 ± 15.95** | 7.33 ± 1.88∗∗▵▵ | |
QSYQ | 6 | 20.67 ± 12.65* | −8.63 ± 4.72▵ | 44.97 ± 21.84 | −1.80 ± 10.43∗∗▵▵ | 55.80 ± 8.23** | 18.90 ± 4.47∗▵▵▴▴ | |
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8 weeks after administration | Sham group | 4 | 7.10 ± 3.18 | 0.59 ± 0.78 | 28.98 ± 6.98 | 2.28 ± 15.25 | 74.88 ± 6.84 | 18.90 ± 12.03 |
Model group | 6 | 21.88 ± 7.65** | 1.83 ± 5.57 | 46.88 ± 13.52* | 3.70 ± 9.44 | 50.71 ± 8.97** | −1.14 ± 1.47 | |
Digoxin group | 6 | 18.03 ± 6.20* | −9.50 ± 6.77∗∗▵▵ | 42.75 ± 7.67 | −8.98 ± 13.71 | 53.98 ± 14.74** | 6.08 ± 0.67∗∗▵▵ | |
QSYQ | 6 | 17.81 ± 8.49 | −11.49 ± 0.56∗∗▵▵ | 30.07 ± 10.09 | −16.70 ± 1.32∗∗▵▵ | 55.87 ± 5.02* | 18.97 ± 7.68∗∗▵▵▴▴ |
Note: *P < 0.05 and **P < 0.01 compared with sham group; ▵ P < 0.05 and ▵▵ P < 0.01 compared with model control group; and ▴ P < 0.05 and ▴▴ P < 0.01 compared with digoxin group.
ΔLVSV = LVSVt − LVSV before administration, ΔLVDV = LVDVt − LVDV before administration, and ΔEF% = EF%t − EF% before administration.