Table 3.
Effects of mTOR siRNA and cisplatin alone or combined on growth of human ESCC xenograft in nude mice (n = 5).
Group | Animal weight | Tumor volume at beginning1 | Tumor volume at termination | Inhibition rate of tumor (%) |
---|---|---|---|---|
Control | 20.54 ± 1.23 | 57.03 ± 10.45 | 999.28 ± 167.30 | — |
siRNA | 20.52 ± 2.08 | 43.62 ± 10.85 | 416.97 ± 38.12* | 58.27 |
cis | 20.38 ± 1.42 | 39.09 ± 2.08 | 367.91 ± 61.21* | 63.18 |
siRNA + cis | 20.66 ± 1.79 | 46.28 ± 25.56 | 232.86 ± 54.23* | 76.70 |
1Tumor volume is expressed as mm3. *P < 0.05, compared to control group.