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Replication kinetics of His mutants in CD4+ T cells. Cell-free wild-type (WT) and mutant viruses were used to challenge 106 CEM-SS cells (A) or SupT1 cells (B). Virus production as measured by reverse transcriptase (RT) activity was monitored after infection. Wild-type and mutant viruses were also used to infect 106 H938 cells, and CAT activity was monitored (C).
