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. 2014 Apr 15;4:4690. doi: 10.1038/srep04690

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(a) Illustration of ICG-encapsulated thermosensitive nanoparticles (NPs) as a USF contrast agent. LCST: lower critical solution temperature. The internal structure of the particles was shown by cutting off one section of the particle. (b) Normalized fluorescence intensity of the four USF contrast agents as a function of the sample temperature. (c) Repeatable switching of the fluorescence intensity of ICG-encapsulated P(NIPAM-AAm 90:10) NPs (as one example). The low and high temperature points are 25 and 44°C, respectively.