Figure 1.

Genetic and phenotypic representation of primary structure variation within the HIV-1 protease consensus. Codons 1–3 are shown in grey and were not included in our analysis. Conserved regions are shown in yellow, semi-conserved regions in ochre, variable regions in orange and highly variable regions in red. The major (dark green) and minor (light green) resistance mutations are indicated for each codon. ^aGenetic variation = total number of mutations at the nucleotide position/number of sequences evaluated. ^bPhenotypic variation = total number of mutations at the amino acid position/number of sequences evaluated.