Table 2.
Natural polymorphisms and unusual mutations of HIV-1 protease (p > 1%) without evidence of resistance to PIs
| Mutation | p (%) | PV (%) | Region (PV) | Classification |
|---|---|---|---|---|
|
L5F |
1.67 |
1.67 |
C (0.95) |
UM |
|
Q7E |
1.52 |
1.89 |
C (0.95) |
UM |
|
T12P/S |
4.03/1.34 |
9.40 |
V (8.04) |
NP/NP |
|
K14R |
9.60 |
11.26 |
V (9.97) |
NP |
|
G17D/E |
1.99/1.32 |
3.31 |
V (9.97) |
UM/UM |
|
Q18H |
1.32 |
3.64 |
V (9.97) |
NP |
|
L19I/V/T |
4.64/1.32/ 1.32 |
7.95 |
V (9.97) |
NP/NP/NP |
|
D29V |
1.32 |
2.65 |
SC(1.24) |
UM |
|
N37S/T/C/H/I |
14.4/2.81/1.99/ 1.66/1.32 |
40.07 |
HV(26.05) |
NP/NP/NP/NP/UM |
|
P39S |
2.98 |
4.97 |
SC(2.09) |
NP |
|
K43R |
3.64 |
3.97 |
SC(2.09) |
NP |
|
Q61E |
2.65 |
3.97 |
SC(4.47) |
NP |
|
L63S/V/R/G/H |
1.99/149/1.99/1.32/1.32 |
84.77 |
HV(22.02) |
NP/NP/UM/UM/NP |
|
E65D |
2.0 |
2.67 |
SC(2.0) |
NP |
|
C67F |
2.0 |
3.33 |
SC(2.0) |
NP |
|
G68E |
4.30 |
5.96 |
V(7.56) |
UM |
|
H69Q |
1.99 |
7.62 |
V(7.56) |
NP |
|
K70R/T/I |
1.99/1.32/1.16 |
9.11 |
V(7.56) |
NP/UM/NP |
|
I72V/T/E/M |
11.26/6.95/2.32/1.32 |
24.50 |
HV(27.48) |
NP/NP/NP/UM |
|
P79L |
1.32 |
2.48 |
SC(1.53) |
UM |
|
T91V |
3.33 |
3.33 |
SC(2.15) |
UM |
|
Q92G/K |
2.03/2.03 |
4.05 |
SC(2.15) |
UM/UM |
| I93F | 1.35 | 47.97 | HV(47.63) | UM |
p, prevalence; PV, phenotypic variation; C, Conserved; SC, semi-conserved; V, variable; HV, highly variable; NP, natural polymorphisms; UM, unusual mutations.