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. 2014 Mar 5;77(4):842–847. doi: 10.1021/np400943b

Figure 3.

Figure 3

Concentration-dependent PPARγ activition by isosilybin A (3) and pioglitazone. HEK-293 cells, transiently transfected with a human PPARγ expression plasmid, a luciferase reporter plasmid (tk-PPREx3-luc), and EGFP as internal control, were treated with different concentrations of pioglitazone or isosilybin A (3) for 18 h. Luciferase activity was normalized by the EGFP-derived fluorescence, and the result is expressed as fold induction compared to the solvent vehicle control (0.1% DMSO). The data points shown are means ± SD of three independent experiments each performed in quadruplicate.