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Tight junction gene regulation in the kidney
| OCLN | ZO-1 | CLDN1 | CLDN4 | CLDN5 | CLDN10b | CLDN16 | CLDN19 | |
|---|---|---|---|---|---|---|---|---|
| Normal |
- |
- |
- |
DKO↑ |
- |
- |
- |
- |
| Ca2+ deficient |
- |
DKO↑ |
9 k↑, DKO↑ |
28 k↑, DKO↑ |
DKO↑ |
28 k↑ |
9 k↑, DKO↑ |
- |
| Ca2+/Vit.D deficient | - | 28 k↑, DKO↑ | - | 28 k↑ DKO↑ | 28 k↑ DKO↑ | 28 k↑ | 28 k↑, DKO↑ | - |
↑: Significantly higher than WT mice, -: no difference, 9 k: CaBP-9 k KO mice, 28 k: CaBP-28 k KO mice, DKO: CaBP-9 k and -28 k double-KO mice.
