. Author manuscript; available in PMC: 2014 Apr 29.

Published in final edited form as: Acta Neuropathol. 2014 Jan 19;127(3):407–418. doi: 10.1007/s00401-013-1239-x

Table 2. TMEM106B genotype affects age at death and age at onset in C9orf72 expansion carriers in a multi-site FTLD-TDP replication cohort.

Linear regressions were used to evaluate the effect of TMEM106B genotype at rs1990622 on the age at death or age at onset in C9orf72(+) FTLD from a multi-site replication cohort of FTLD-TDP cases. rs1990622 genotype was significantly associated with both age at death and age at onset, in both univariate models and models adjusting for age and presence/absence of motor neuron disease (MND). Asterisks denote significance.

Disease	Outcome	Predictors	Beta (rs1990622, each major allele)	R² for model	P-value (rs1990622)
FTLD-TDP	Age at Death (n=75)	rs1990622	+3.342	0.048	0.016 *
	Age at Death (n=75)	rs1990622, Sex, MND	+3.413	0.032	0.019 *
	Age at Onset (n=68)	rs1990622	+3.473	0.049	0.019 *
	Age at Onset (n=68)	rs1990622, Sex, MND	+3.198	0.057	0.032 *