Table 3. TMEM106B rs1990622 genotype is associated with FTLD-TDP in all genetic subgroups.

Chi-square tests were performed to evaluate for association between disease and rs1990622 genotype for FTLD-TDP subgroups defined by the presence of GRN mutations (GRN(+) FTLD-TDP), presence of C9orf72 expansions (C9orf72(+) FTLD-TDP), or the absence of both genetic mutations (FTLD-TDP (no mutation)). The major allele was significantly associated with disease in all three subgroups. Allele frequencies for normal controls provided here are from our previously published GWAS.

Disease status	N	rs1990622 Major allele T	rs1990622 Minor allele C	p-value	Odds ratio	95% CI
Normal	2509	0.564	0.436	-
GRN(+) FTLD-TDP	116	0.776	0.224	<0.0001	2.675	1.955–3.660
C9orf72(+)FTLD-TDP	80	0.669	0.331	0.008	1.560	1.117–2.179
FTLD-TDP (no mutation)	241	0.640	0.360	0.001	1.375	1.131–1.671