Table 1. Clinical Characteristics of Hording Disorder Subjects.
Clinical characteristics, treatment history, and outcome of four HD patients treated with adjunctive methylphenidate extended release (MPH-ER) for 4 weeks. The continuous performance task (CPT) is reported at the interstimulus intervals of 1000milliseconds and 4000 milliseconds, with the reaction time standard deviation (SD) and mean reaction time also reported in units of milliseconds.
| Pt No | Age/Sex | Race | Comorbid Dx SCID | Prior SRI/ SNRI Trials |
Current Medications | Maximum MPH-ER Dose | Side Effects | ADHDSS Score Pre/Post |
SI-R Score Pre/ Post/% reduction |
Mean Reaction Time CPT (ISI=1000) re/Post/% reduction |
Mean Reaction Time CPT (ISI=4000) re/Post/% reduction |
Reaction Time SD CPT (ISI=1000) re/Post/% reduction |
Reaction Time SD CPT (ISI=4000) re/Post/% reduction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 48/F | AA | OCD, MDD Specific Phobia | 3 | None | 54mg | Insomnia | 19/20 (↓ 0%) |
75/75 (↓ 0%) |
395/386 (↓ 2%) |
458/452 (↓ 1%) |
58/39 (↓ 33%) |
72/48 (↓ 34%) |
| 2 | 45/F | C | MDD, Social Phobia | 1 | None | 36mg | Palpitations | 30/10c (↓ 67%) |
59/40d
(↓ 32%) |
430/391 (↓ 9%) |
489/461 (↓ 6%) |
118/64 (↓ 46%) |
123/322 (↓ 6%) c |
| 3 | 42/M | C | MDD | 3 | Duloxetine, a
escitalopram, bupropion |
54mg | Insomina | 20/10 c (↓ 50%) |
64/62 (↓ 0%) c |
424/414 (↓ 2%) |
584/499 (↓ 15%) |
71/51 (↓ 28%) |
156/73 (↓ 53%) |
| 4 | 36/F | C | Dysthymia, GAD | 3 | Citalopram, b clonazepam |
54mg | Insomina, headache, decreased appetite |
43/16 c (↓ 63%) |
71/53d
(↓ 25%) c |
476/390 (↓ 18%) | 467/436 (↓
7%) c |
122/83 (↓ 32%) | 98/94 (↓ 4%) |
AA, African American; ADHDSS, ADHD Symptom Scale; C, Caucasian; CPT, continuous performance test response time; F, female; GAD, generalized anxiety disorder; ISI, interstimulus interval; M, male; MDD, major depressive disorder; OCD, obsessive-compulsive disorder; SI-R, Saving Inventory-Revised; SRI, serotonin reuptake inhibitor; SNRI, serotonin and norepinephrine reuptake inhibitor.
Patient #3, duloxetine 30mg daily, escitalopram 10mg daily, bupropion 300mg daily, all stable for 15 years
Patient #4, citalopram 60mg daily for 12 weeks, clonazepam 2mg daily for 8 weeks
>30% reduction in ADHDSS
>25% reduction in SI-R