Table 1.
Summary of E. coli K1 RS218 derived islands (RDI's) and its genomic islands mutants tested in the present study.
| E. coli K1 | |
|---|---|
| Identity | Function and potential virulence factor |
| K1 (RS218) | Isolate from a meningitis patient. |
| Plasmid cured RS218 | Plasmid-free strain |
| RS218 complemented with HB101 DNA | Strain, in which genomic deletion (black hole) observed in RS218 was filled with respective DNA from HB101 |
| RDI 1 | Invasins (IcmF and IcmH). |
| RDI 2 | Prophage genes. |
| RDI 4 | Adhesins (S fimbriae, antigen 43). Protein secretion system (T5SS for antigen 43). Iron uptake system (Iro system and hmu system). |
| RDI 9 | Iron uptake system (Ybt system). |
| RDI 10 | Toxins (peptide toxin). |
| RDI 12 | Other virulence factors (sia operon). Prophage genes. |
| RDI 14 | Prophage genes. |
| RDI 15 | Metabolism (sugar metabolism). |
| RDI 16 | Protein secretion system (T2SS). Other virulence factors (K1 capsule biosynthesis). |
| RDI 17 | Metabolism (phosphor-sugar metabolism). |
| RDI 18 | Prophage genes. |
| RDI 21 | Adhesins (P fimbriae, F17-like fimbriae, non-fimbrial adhesins, Hek and hemagglutinin). Protein secretion system (T1SS for hemolysin). Invasins (CNF1). Metabolism (D-serine catabolism). |
| RDI 22 | Invasins (IbeA). Toxins (α-hemolysin). Metabolism (dihydroxyacetone, glycerol, and glyoxylate metabolism). |