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. 2013 Dec 19;20(5):433–441. doi: 10.1093/molehr/gat095

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© The Author 2013. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Differential effects of 17β-estradiol and ER agonists on human myometrial and placental arteries. Myometrial (A–D) or placental (E–H) arteries were preconstricted with U46619 and exposed to incremental doses of estrogenic compounds. Representative raw tracings are displayed in A–C, E–G, summary data (mean ± SEM, n = 6) in D and H. 17β-estradiol or ERβ agonist, DPN relaxed myometrial arteries to a greater extent than placental arteries whereas ERα agonist, PPT relaxed only myometrial arteries. GPER-1 agonist (G1) was without effect in either artery type. *Significant differences from time control (TC).