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. Author manuscript; available in PMC: 2014 Apr 29.
Published in final edited form as: Behav Brain Res. 2013 Jan 17;243:255–260. doi: 10.1016/j.bbr.2013.01.014

Figure 4.

Figure 4

Acute i.p. administration of cocaine attenuates the phase-delaying response to photic stimulation during early night (ZT 16) in Per2 mutant and WT mice. Left panel: graphic representation of the phase-delaying responses to light following cocaine and control treatments. Bars represent means±SEM. Bars with different letters are significantly different within and between strains (p<0.05). Right panel: representative double-plotted actograms of general locomotor activity showing phase-resetting responses to light following cocaine and control treatments (open star designates onset of treatment). The light and dark phases of the LD cycle are represented above the actograms by the open and filled horizontal spaces, respectively. The shaded portion designates constant darkness following drug treatment (star).