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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Cancer Immunol Res. 2013 Dec 17;2(4):341–350. doi: 10.1158/2326-6066.CIR-13-0138

Figure 4.

Figure 4

Effect of inhibitors for antigen degradation on the recognition of SK37 by TR-CD4. (A, B) SK37 was cultured for 16–20 hours with or without indicated proteasome inhibitors (A) or protease inhibitors (B) followed by fixing with paraformaldehyde and extensive washes. SK37 was co-cultured for 20 hours with TR-CD4. IFN-γ level in the supernatant was measured by ELISA. Results are shown as % inhibition of IFN-γ production compared to untreated target cells. Statistical significance was calculated by Student’s t-test and is shown as *:P ≤ 0.05 and **:P ≤ 0.01.