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Inhibition of nitric oxide (NO) synthesis restores proliferation in IL-1-activated chondrocytes. Cells were treated as for Fig. 2, but with the addition of N-monomethyl-L-arginine (L-NMA) at a final concentration of 0.5 mM 30 min before IL-1. Values are the mean ± standard error of n = 9–-12. *P < 0.05 versus IL-1 alone, #P < 0.05 versus IL + L-NMA. FCS, fetal calf serum; IGF, insulin-like growth factor 1; SB, SB 203580; TGF, transforming growth factor beta.
