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SB 203580 (SB) inhibits transforming growth factor beta (TGF-β)-stimulated and IL-1-stimulated prostaglandin E2 (PGE2) synthesis by lapine chondrocytes. Chondrocytes were treated as in Fig. 4 and conditioned media collected for assay of PGE2 24 hours after activation. Values are the mean ± standard error of n = 6–9. SB 203580 significantly inhibited PGE2 production in all conditions except 'control'.
