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Novel 1 nt sequence variations detected in miRNAs. Five novel heterozygous variations, localized in various miRNA regions, were detected by resequencing microarray and confirmed by Sanger sequencing in five different CLL patients: (A) pri-miR-29a, (B) pre-miR-16-1, (C) pre-miR-372, (D) pre-miR-106b, (E) miR-142-3p.
Variations localized downstream of the precursor hairpin, which contains the mature miRNA, are assigned ‘+’.
