Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Dec 4;35(5):992–1002. doi: 10.1093/carcin/bgt396

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Fig. 4. — Secondary structures of wt miRNAs and miRNAs harboring sequence variations (novel variation/SNP) predicted by the RNAfold tool. (A) The novel variation found in pre-miR-16-1 (83G>C) had a dramatic effect on its secondary structure, whereas the known mutation present in its primary region (+7C>T) (9) had none. (B) pri-miR-29b-2 secondary structure was affected by polymorphic insertion (rs141961287: +107+A).

Depicted are the most stable secondary structures with the lowest free energy as predicted by the RNAfold tool. Variations are designated in red and indicated by arrows. Mature miRNAs and miR-5p are designated in violet; mature miRNAs* and miR-3p are designated in blue. Pre-miRNA regions are designated in green; pri-miRNA regions are colorless.