Table II.
Novel 1 nt sequence variations detected in miRNAs
| miRNA | Locationa | Chromosomal variant (hg19) | Reference allele | Alternative allele | CLL patients (n = 98/213) | Origin | Control subjects (n = 1092) | Comment |
|---|---|---|---|---|---|---|---|---|
| mat-miR-142-3p | 62C>T | NC_000017.10:g.56408618G>A | G | A | 1/98 | NA | 0/1092 | No cancer history |
| pre-miR-16-1 | 83G>C | NC_000013.10:g.50623115C>G | C | G | 1/98 | Germline | 0/1092 | Father - bladder cancer |
| pre-miR-372 | 13T>C | NC_000019.9:g.54291156T>C | T | C | 1/98 | Germline | 0/1092 | No cancer history |
| pre-miR-106b | 45C>T | NC_000007.13:g.99651653G>A | G | A | 1/98 | NA | 0/1092 | NA |
| pri-miR-29a | +22T>C | NC_000007.13:g.130561484A>G | A | G | 1/98 | NA | 0/1092 | Father - colon cancer |
| pri-miR-29b-2 | −256A>G | NC_000001.10:g.207976124T>C | T | C | 2/213 | 1 Germline, 1 NA | 0/1092 | The patient with germline variation - uncle and his son had CLL |
aNovel variations localized upstream (negative base count, ‘−’) or downstream (positive base count, ‘+’) of the precursor hairpin. NA, not available.