. 2014 Jan 13;35(5):1039–1045. doi: 10.1093/carcin/bgu010

Table IV.

Top genes interacting with smoking at $P < 0.0005$

Gene	Gene description	No. of SNPs/ eigenSNPs^a	P _{(G × E)} ^b	P value for marginal association^b
Gene	Gene description	No. of SNPs/ eigenSNPs^a	P _{(G × E)} ^b	≥20 Pack-years	<20 Pack-years^c
ZBED2	Zinc finger BED domain-containing protein 2	4/3	0.00013	0.00053	0.38
EXO1	Exonuclease 1	19/7	0.00017	0.17	0.033
PSG2	Pregnancy-specific beta-1-glycoprotein 2	3/3	0.00019	0.035	0.15
SLC36A1	Proton-coupled amino acid transporter 1	28/5	0.00022	0.089	0.047
CLSTN1	Calsyntenin-1	10/4	0.00023	0.00088	0.64
MTHFSD	Methenyltetrahydrofolate synthase domain-containing protein	24/7	0.00036	0.03	0.057
FAT2	Protocadherin Fat 2	35/8	0.00038	0.047	0.036
IL10RB	Interleukin-10 receptor subunit beta	17/7	0.00043	0.016	0.035
ATXN2	Ataxin-2	7/2	0.00047	0.21	0.0029

^aNumber of SNPs in the gene/number of principal components used for the analysis.

^bObtained from LRT in logistic regression with adjustment for age, sex, study, diabetes, and five principal components for population substructure.

^cIncluding non-smokers.